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Kappe C, Tracy LM, Patrone C, Iverfeldt K, Sjholm

Abstract Despite Polycystic Ovary Syndrome (PCOS) is a very prevalent disorder among women of reproductive age, there is widespread agreement that until now, no pharmacological options are available to tackle the entire spectrum of clinical manifestations encountered in the clinical practice

That includes an oral drug that blocks another gut hormone called GIPR, which entered phase two trials last year, and an additional once-daily oral GLP-1 in phase one trials

Despite this broad therapeutic interest, certain domainsparticularly skeletal muscle biology and neurodegenerationillustrate a recurring translational mismatch between mechanistic signaling effects and clinical functional outcomes

MarguliesKBHernandezAFRedfieldMMGivertzMMOliveiraGHColeRet alEffects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial