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SAHPRA has not authorised/registered Ozempic for weight-loss, therefore, use in that regard would be off-label

GLP-1 is a natural hormone predominantly produced in the small intestine, with minor synthesis occurring in the pancreas and the brain

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The association between GLP-1 RA exposure and the odds of SUD was estimated to use conditional logistic regression, which accounted for the nested case control design

The ventral tegmental area, where dopaminergic neurons originate, also expresses GLP-1 receptors

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