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In Phase 2 trial settings, participants have shown gradual but meaningful reductions in body weight over several months, alongside improvements in blood glucose control, blood pressure, and metabolic markers

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For all patients diagnosed with diabetes, changes to their diet will be recommended

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Several studies have reported an inverse relationship between BMI and therapeutic efficacy, indicating that obesity may attenuate clinical responses to biologic disease modifying anti-rheumatic drugs (bDMARDs)