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Most patients experience symptom resolution within 48 weeks as their gastrointestinal tract adapts

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doi: 10.2337/dc16-0690 57 MathieuCZinmanBHemmingssonJUWooVColmanPChristiansenEet al

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People with leptin gene mutations are obese secondary to pronounced hyperphagia [84], and satiety and body weight can be regulated in people with these genetic mutations with leptin treatment [85]

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Learning to recognize and respect these new, sometimes more subtle, signals of fullness is essential

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Funding None to disclose

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Cellular cAMP determination assay Freshly isolated CSMCs were cultured in DMEM supplemented with 10% FBS, 100 U/mL of penicillin, and 100 g/mL of streptomycin at 37 C in 5% CO 2

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