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TRIUMPH1 also has a nested OA trial that, similar to the TRIUMPH4 standalone OA trial, includes participants with obesity with knee pain and radiographic evidence of knee OA

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10.1111/pedi.12787 [DOI] [PubMed] [Google Scholar] McNamara P

HFD feeding Male C57BL/6J, AMPK-KO and CKMT1-KO mice were fed a HFD (42% fat and 0.25% cholesterol, AIN93G, LabDiet), starting at 12 weeks of age and for a duration of 8 weeks for metabolic evaluations
