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Moreover, in subjects with diabetes who were at high risk of cardiovascular events, treatment with GLP-1R agonists based on the structure of endogenous GLP-1, namely liraglutide, semaglutide, albiglutide, and dulaglutide, has demonstrated reductions in major adverse cardiovascular events (MACEs) that appear to be unrelated to the glycemic effects of these agents (1316)

GLP-1 agonists has protective effects against inflammation and oxidative stress on human endothelial cells, including those injured by inflammatory mediators like tumor necrosis factor (TNF)- [57]

Overall, someone can start looking older, and thats what we refer to as Ozempic face, says Dr

doi: 10.1016/j.jnutbio.2018.07.009 70 ZhaoLChenYXiaFAbudukerimuBZhangWGuoYet al

The AWARD-7 trial, which was the first clinical trial among moderate-to-severe CKD and T2DM displayed convincing protective effects on eGFR after treatment with GLP-1RAs [46]

The molecular mechanisms leading to diminished GLP-1 responsiveness associated with genetic variation in TCF7L2 most likely includes alterations of the WNT signaling pathway and associated -cell proliferation and insulin gene expression [566]