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Additionally a meta-analysis found use of GLP-1RA was associated with higher risk of gallbladder and biliary disease with high doses for longer duration (113)

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Somatostatin, secreted from pancreatic -cells, acts as an inhibitory paracrine to suppress glucagon release from pancreatic -cells, and specific blockade of SSRT2 eliminates the inhibitory effect of GLP-1 on glucagon secretion
