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Retatrutide GLP-3 Vial All Retatrutide GLP-3 research Retatrutide (development code LY3437943) is a synthetic, once-weekly triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors that has been the subject of peer-reviewed phase 1 and phase 2 randomized controlled trials published in The New England Journal of Medicine, The Lancet, and Nature Medicine, including investigations of body weight, glycemic control, and hepatic steatosis in adult human participants

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Contrave users saw a body weight reduction of approximately 5 to 10% over about one year

Zaczek Z, Jurczak-Kobus P, Panczyk M, Braszczynska-Sochacka J, Majewska K, Kunecki M, et al

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These findings suggest that retatrutide may offer broader cardiometabolic benefit beyond blood pressure reduction alone