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We also included markers of diabetes severity, including duration (in years [continuous]), complications (yes vs no), hemoglobin A 1c value (continuous), and use (yes vs no) and duration (in years [continuous]) of diabetes medications (metformin, insulin, sulfonylureas, or glitazones)

Studying 979 patients who had overweight or obesity, researchers found 20 cases of NAION in people prescribed semaglutide, calculated as a cumulative rate of 6.7%

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Avoid fried, spicy, and high-fat foods within 48 hours of dosing, as these intensify stomach distress and can worsen nausea by 3050%

Cigna may require step therapy, meaning patients must try a less expensive medication such as Contrave before the insurer approves a GLP-1 agonist

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