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J Clin Endocrinol Metab 94:28872892

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Systematic metabolic benefits In circulation, GLP-1 is primarily produced by intestinal L cells and pancreatic cells (its activity remains controversial), stimulated by the digestion of food or bile acids

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Mechanism of Action The mechanism of action of semaglutide is multifaceted, addressing several aspects of diabetes management

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Abstract Introduction Oral semaglutide is the first orally administered glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes, and has been evaluated in the PIONEER clinical trial program

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