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Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear

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The interest raised by this molecule is linked to the approval of DPP-4 inhibitors for T2D treatment (gliptins as vildagliptin, saxagliptin, alogliptin, sitagliptin, and linagliptin), as monotherapy or as an adjunctive agent with other drugs, with numerous advantages with respect to traditional treatments [53]

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All in all, while identification of the molecular mechanisms for its beneficial metabolic effects warrants further investigation, our proteomic data strongly suggest a distinctive role of central actions of GLP1/E for the amelioration of the metabolic profiles of our PCOS models