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For example, in ApoE-deficient mice, GIP analogs significantly reduced atherosclerosis and improved vascular function ( 5.2 Prospective clinical trial progress and results of tirzepatide in the treatment of type 2 diabetes with cardiovascular disease Currently, two significant cardiovascular outcome trials for tirzepatide are underway (or have recently concluded), including SURPASS-CVOT and SUMMIT

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For someone on a GLP-1 medication, this is counterproductive

Tolerance can develop over 812 weeks in some patients, though research suggests this is more related to central nervous system adaptation than to reduced gastric effects

They show some promise in helping with binge-type eating disorders, but we dont quite know yet which patients will benefit and which patients will be harmed, Dennis explained

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