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Am J Physiol Renal Physiol (2010) 298(1):F17786

Adverse Reactions/Side Effects The following adverse reactions are also discussed elsewhere in the labeling: Lactic Acidosis [see Warnings and Precautions (5.1)] Pancreatitis [see Warnings and Precautions (5.2)] Heart Failure [see Warnings and Precautions (5.3)] Acute Renal Failure [see Warnings and Precautions (5.4)] Vitamin B12 Deficiency [see Warnings and Precautions (5.5)] Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues [see Warnings and Precautions (5.6)] Hypersensitivity Reactions [see Warnings and Precautions (5.7)] Severe and Disabling Arthralgia [see Warnings and Precautions (5.8)] Bullous Pemphigoid [see Warnings and Precautions (5.9)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

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[DOI] [PubMed] [Google Scholar] 90.Yoshida Y, Joshi P, Barri S, Wang J, Corder AL, OConnell SS, et al

[DOI] [PubMed] [Google Scholar] 14.de Zeeuw D, Akizawa T, Audhya P, Bakris GL, Chin M, Christ-Schmidt H, et al

Evidence from Human In Vitro and Clinical Studies on the Effect of GLP-1 RAs on Disease Activity in Non-IBD Immune-Mediated Inflammatory Diseases (IMIDs) Only three human (one in PsO and two in rheumatoid arthritis (RA)) in vitro studies met the eligibility criteria for inclusion as basic science evidence that GLP-1RAs have therapeutic anti-inflammatory potential for treating non-IBD IMIDs (Table 2)
