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Glucagon receptor agonism stimulates hepatic glucose production, increases lipolysis (fat breakdown), promotes fatty acid oxidation in the liver, and elevates resting metabolic rate through thermogenesis

Key metabolic hormones (including glucagon-like peptide-1 (GLP-1), leptin, ghrelin, and cholecystokinin (CCK) play dual roles: not only regulating hunger and metabolism, but also directly modulating the activity and expression of taste receptors throughout the oral cavity and gastrointestinal tract

A.LicznerskiP.et al

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Lastly, our rigorous analytic procedures with a series of sensitivity and subgroup analyses that varied with different clinical scenarios ensure the robustness of our study findings and their generalizability to diverse real-world T2D populations treated with GLP-1RAs