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Trends that fail to reach significance in meta-analyses of 45 trials are, by definition, small effects that may or may not be real

Given that PCOS is frequently comorbid with steatotic liver disease and hypertriglyceridemia, we recommend intensified screening for gallbladder symptoms (e.g., right upper quadrant pain, fatty food intolerance) and regular monitoring of hepatobiliary markers during phases of rapid weight loss

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doi: 10.6061/clinics/2014(12)07

Tirzepatide induces ferroptosis in glioblastoma cell lines via the SOX2/SLC7A11 axis: a potential therapeutic strategy for glioma treatment

Future studies should therefore incorporate standardized assessments of body composition, pubertal staging, and longitudinal growth parameters to ensure that weight-loss efficacy is not achieved at the expense of healthy developmental processes