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The pipeline reflects the industry's focus on three goals: longer dosing intervals (every two weeks instead of weekly), oral formulations (to avoid injections), and multi-receptor agonism (to push past the 15% to 17% weight loss ceiling of pure GLP-1 agonists)

Platforms like Joi + Blokes operate within this telehealth model, connecting patients with independent clinicians who evaluate eligibility remotely

To synthesize the findings discussed across different substance classes, Table 2 summarizes the neurobiological mechanisms by which GLP-1 receptor agonists modulate addiction-related behaviors in preclinical models

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Hinojosa emphasizes that patients without symptoms typically do not need to stop their medication