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Dominari, A., et al

The request for a standalone MDL follows studies from Harvard and JAMA Ophthalmology suggesting that GLP-1 drugs may increase the risk of NAION up to sevenfold

Importantly, when researchers blocked the GLP-1 receptor by injecting its inhibitor into the joint, the protective effects disappeared

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The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords