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tirzepatide has not been studied in patients with a history of pancreatitis, and alternative therapy should be considered in these individuals Gallbladder disease : Rapid weight loss increases cholelithiasis risk

doi: 10.1002/micr.30855 6 ChangDWDayanJGreeneAKMacDonaldJKMasiaJMehraraBet al

Like Liraglutide (Novo Nordisk, Copenhagen, Denmark), it is based upon the native GLP-1 sequence

PMID: 39624804

Highlights of Prescribing Information: Trulicity (dulaglutide) injection, for subcutaneous use

Other GLP-1R, GIPR, and glucagon receptor (GCGR) poly-agonists are in development and have been tested in phase 1 and phase 2 clinical trials, including GLP-1R/GCGR agonists, GLP-1R/GLP-2R agonists, and triple GLP-1R/GIPR/GCGR agonists (abstracts presented at the American Diabetes Association Annual Meeting in June, 2022 and (7))