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This heightened risk might be associated with the exacerbation of chronic inflammatory states in patients undergoing prolonged combination therapy, potentially facilitating carcinogenic processes [8]

doi: 10.1371/journal.pone.0199508

The brand doesnt highlight required lab work or ongoing metabolic monitoring, so patients who want a deep clinical dive or have a complicated medical history may find it lacking

Furthermore, studies using a peripherally administered exenatide analogue conjugated to vitamin B12, which is sterically hindered from accessing regions protected by the blood brain barrier, improves glucose control in comparable fashion to unmodified exenatide, presumably at the level of the -cell, but does not induce emesis in the house musk shrew ( Suncus murinus) or rats (78, 79)