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A review of placebo-controlled trials of GLP-1RA and SGLT2-I in T2DM, with or without baseline MET therapy, suggests that both the classes are likely similar in efficacy, lowering A1c by 1%1.5%

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Overweight and obesity management | NICE

Avoid dose escalation while GI AEs persist

The Wegovy pill showed roughly similar weight loss and side effects in clinical trials as the Wegovy shot, and will be available by prescription in the US in January, according to Novo Nordisk

356,357 The activated AMPK pathway can upregulate the expression of FTH1 and GPX4 in intestinal tissues and can improve iron metabolism and redox disorders in the colons of UC rats, thereby effectively treating UC