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One possibility is that since ductal replication is increased with obesity or type 2 diabetes (24), and GLP-1 may amplify this, studies in lean nondiabetic animals may have had a limited propensity to GLP-1induced pancreatitis

The findings are a wake-up call that we cannot afford to ignore

For example, both semaglutide and tirzepatide, in addition to their primary indications for type 2 diabetes and obesity, have demonstrated cardiovascular benefits

A 2023 study out of the University of British Columbia found that GLP-1 drugs were associated with an increased risk of stomach paralysis, pancreatitis and bowel obstruction

Despite these mechanistic differences, both drug classes consistently outperform many other therapeutic options in reducing anthropometric parameters such as body weight and body mass index

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