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Janumet XR is contraindicated in severe renal impairment, including an estimated glomerular filtration rate below 30 mL/min/1.73 m2

Zepbound is also indicated for people with moderate to severe obstructive sleep apnea and obesity

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Incretin-based drugs and the incidence of prostate cancer among patients with type 2 diabetes

In the trials cited above, participants maintained steady loss across 68 to 72 weeks with ongoing support