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How Foundayo Weight Loss Results Compare With the Wegovy Pill By the end of the study, people on the highest dose lost an average of about 27 pounds (12.4 percent of their starting body weight), compared with average weight loss of just 2.2 pounds with the placebo

Conversely, at current prices, GLP-1 RAs are unlikely to meet the arbitrary AU$28,000 per QALY willingness-to-pay threshold in either the total or secondary prevention population when considering only their benefits on CVD

doi:10.1016/S2213-8587(15)00482-9 17

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SGLT2 inhibitors were chosen as the comparator given they are guideline-recommended second-line glucose-lowering medication and share similar cardiovascular benefits with GLP-1RA, which helps reduce confounding by indication

The most common AEs recorded following administration of PF-06882961 were nausea, vomiting, and decreased appetite, all of which were considered treatment-related by the investigator and consistent with the expected effects of the GLP-1R agonist mechanism