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Adding glucagon receptor activation drives additional energy expenditure beyond what dual or single agonists produce, which shows up in the trial data

Wettergren A, Wjdemann M, Holst JJ

Tirzepatide (Zepbound) is FDA approved for weight management

It is engineered to activate three distinct hormonal receptors simultaneously: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor (GCGR)

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