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It followed a predictable pattern tied directly to tirzepatide clearance from the body
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Interleukin-6 is a pro-inflammatory cytokine directly implicated in SLE pathogenesis

The 72-hour rule The FDA prescribing information is clear on this point

However, it has not been approved in the United States, European Union, or most other markets

tirzepatide also led to a mean body weight reduction of 20.1% from baseline, compared to 2.3% from baseline for placebo
