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Ahmann, A

An alternative emphasis on spatial localization of GcgR signaling for the mediation of downstream outcomes is the reliance of maximal hepatic transcriptional upregulation of genes such phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, on the full internalization of the ligand-bound glucagon receptor [21]

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Although use of GLP-1RAs does not increase the risk of severe hypoglycaemia, 10 it may elevate the risk of hypoglycaemia caused by insulin and sulfonylureas if prescribed with these agents

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