glp-1 receptor agonists in pediatric and adolescent obesity GLP‐1 for Psychopharmacology: Opportunities Cautions - Bartkoski - 2025 - Clinical and Translational Science GLP1 Receptor Agonists—Effects beyond Obesity

Diabetes Care 33 , 23492354 (2010)

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Finally, it is important to highlight the immunomodulatory effects of tirzepatide

A 2025 perspective suggested GLP-1s may influence epigenetic processes involved in age-related liver fibrosis and cancer risk [6]

Importantly Exendin-4 has a mutation that blocks its cleavage extending its half-life to 2.4 h

These categories included genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication [2]