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In addition, hyperinsulinemia is responsible for the increase in the androgen production through both the direct stimulation of insulin receptors and the cross-reaction with Insulin-like Growth Factor-1 (IGF-1) receptors expressed on thecal cells [14]

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Click to read the study, published today in JAMA Relevant Reading: Treatment of primary Sjgren syndrome: a systematic review In-Depth [randomized controlled trial]: This study randomized 120 individuals with SS to receive hydroxychloroquine or placebo for 24 weeks and measured their numeric analog scales on three domains: dryness, fatigue, and pain

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