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For researchers, this highlights the need to stratify outcomes not only by dose but also by starting weight, ensuring that comparisons across arms are meaningful

As a result, interferences with insulin signaling begin such as impairment of mitochondrial function and muscle oxidative capacity, and activation of molecular inflammatory pathways (i.e., protein kinase C, nuclear factor kB, and toll-like receptor 4 (TLR4) networks) [66]

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