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Regarding the inconsistency of the aforementioned results, we hypothesize that it may be attributed to the following factors: (1) Drug structure and receptor binding specificity: Inherent variations exist in the molecular structure, half-life, and receptor binding efficacy among different GLP-1RAs, which directly determine their functional selectivity for atrial cardiomyocytes

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Key variants like GLP1R rs6923761 and GIPR rs1800437 reveal whether your body is naturally more or less responsive to GLP-1 agonists, helping inform dose optimization and protocol choice

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Spranger S., Gajewski T.F

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