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In the pancreas, beta cell-specific genes, such as Ins1 and Ins2 , exhibit a significant decline in the positive control (PC) group followed by a gradual dose-dependent significant increase in the treatment groups (GS1, GS2) (Figure 6A)

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Exenatide treatment (10 g per dog BID for 12 weeks) led to weight loss, but did not affect food consumption, fasting glucose, insulin, glycated hemoglobin or OGTT

P = 0,25)

The pharmacokinetics of sitagliptin was generally similar in healthy subjects and in patients with type 2 diabetes mellitus