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When the body undergoes rapid fat loss, it interprets the change as a stress signal

Super responders lose weight quickly, while non-responders do not see treatment benefits

After propensity score matching (18,386 patients), researchers found: Patients receiving tirzepatide were 1.76 times more likely to achieve 5% weight loss 2.54 times more likely to achieve 10% weight loss 3.24 times more likely to achieve 15% weight loss At 12 months, the difference in weight change was 6.9 percentage points favoring tirzepatide

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Shared signaling pathways Estrogen and GLP-1 activate different receptors
