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For other potential indications such as substance use disorders or depression, more randomized controlled trials in humans are still needed

both exenatide and metformin had similar effects on microvascular endothelial function measured by the reactive hyperemic index (RHI), as well as levels of inflammatory and oxidative stress markers including C-reactive protein (CRP), oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) levels [63]

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Notably, GLP-1RA treatment increased the relative abundance of N, N-dimethyl sphingosine (DMS), an endogenous metabolite derived from sphingosine

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