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New treatments, including GLP-1 medications like Ozempic, have offered hope to many for weight management and diabetes control

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In contrast, CNS, but not vagal, GLP-1Rs were required for a complete anorectic response to the long-acting GLP-1R agonist liraglutide and the anorectic and weight loss effects of chronic liraglutide treatment

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Particularly, liraglutide attenuates pre-established atherosclerosis throughout the aorta and aortic root in ApoE -/- mice via increasing macrophage polarization into anti-inflammatory macrophages and by reducing the number of pro-inflammatory macrophages [92]