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Diabetes Care 2023;46(Supplement_1):S140S157

Patients with T2D not adequately controlled on therapy with metformin and insulin glargine as baseline therapy received either tirzepatide at the doses used in the SURPASS trials or placebo during the 40-week study setting

It slows food movement through the digestive tract, making the person feel fuller for longer, helping the liver regulate sugar production, and reducing food cravings

27 The attachment of fatty acid chains to Lys 16 via an amido bond does not conspicuously influence GIP activity

Dose Adjustments for Tolerability If youre struggling with side effects at a particular dose, your provider might recommend staying at that dose longer (six to eight weeks instead of four), temporarily dropping back to your previous dose for a few weeks, then trying to increase again, or increasing by smaller increments if thats feasible with available dosing options

Contraindications and Warnings Contraindications for tirzepatide use include a history of pancreatitis, severe gastrointestinal disease, or hypersensitivity to the active substance