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However, their efficacy is driven primarily by appetite suppression rather than sustained increases in energy expenditure, and adult human physiology imposes a clear ceiling on thermogenic contributions

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Int J Obes (Lond) 48:11181125 Gorgojo-Martnez JJ, Basagoiti-Carreo B, Sanz-Velasco A et al (2019) Effectiveness and tolerability of Orlistat and liraglutide in patients with obesity in a real-world setting: the XENSOR study