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sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

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Inflammation, mitochondrial impairment, oxidative stress, and insulin resistance may all contribute to disease progression

sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

doi: 10.1016/j.molmet.2022.101550 51 RazzakiTSWeinerAShuklaAP

sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

MeAgain is a technology platform and does not provide medical advice, diagnosis, or treatment

sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

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sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

Genetics and other individual factors are likely involved

sglt2 inhibitors vs glp-1 agonists View of Diabetes medications with cardiovascular protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, and long-acting receptor complement each other to save lives by different mechanisms? Cardiorenal Protection: Potential of SGLT2

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