glp-1 for autoimmune inflammation Medications Arthritis & Disease Anti-Inflammatory Effects of GLP-1-Based Therapies

Future Directions Identifying HF subgroups most likely to benefit from GLP-1 RAs will optimise patient selection and clinical outcomes

doi: 10.1016/j.cmet.2025.06.012

Innovators will also need to reassure HCPs about the safety of these new therapies to address potential concerns or overcome pre-conceptions

GIPs action to augment splanchnic blood flow, potentially affecting nutrient uptake and its involvement in adipose tissue metabolism and suggested central affects in the regulation of appetite as seen in animal models, all remain to be further explored in humans

The safety and effectiveness of RYBELSUS was evaluated in a 26-week clinical study that included 324 patients with moderate renal impairment (eGFR 30 to 59 mL/min/1.73 m2) [see Clinical Studies (14.1)]

GLP-1 receptor agonist exenatide attenuates the detrimental effects of obesity on inflammatory profile in testis and sperm quality in mice