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Providing mechanistic insights into the relative contribution of each receptor pathway to overall metabolic outcomes
In NOD mice, treatment with the DPP4 inhibitor MK0431 prolonged the survival of islet grafts and reduced CD4+ T cell migration into the pancreas through the cAMP/PKA/Rac1 activation pathway
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Why Slowed Digestion Matters The primary mechanism being investigated is gastroparesis or significantly delayed gastric emptying
