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Fat Metabolism Changes: GIP receptors in fat tissue may influence how your body stores and uses fat, potentially increasing fat burning

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Berberine also inhibits PCSK9 (which increases the liver's ability to clear LDL from the bloodstream), inhibits DPP-4 (which extends the activity window of natural GLP-1), and directly affects gut microbiome composition in ways that may further support metabolic function

This raises concerns about potential conflicts of interest and the need for independent research

However, this approach must be considered as an add-on rather than an alternative to the search for novel drugs