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Why this matters: Earlier single-center data suggested a higher risk (HR ~ 4.3), but larger, more representative analyses now paint a more reassuring picture

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A massive effort by chemists at the Eli Lilly pharmaceutical company finally resulted in a viable synthesis, but why this massive effort

Large-scale pharmacoepidemiological data has not demonstrated a statistically significant increase in suicidal behaviour but there are important signals in specific subgroups, particularly those already on antidepressants or benzodiazepines