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Randomization and treatment Participants were randomly assigned in a 2:1 ratio to receive once-weekly subcutaneous injections of survodutide 6.0 mg (maintenance dose) or placebo (Extended Data Fig

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But similar to liraglutide and semaglutide, which do not cross the BBB [[944], [945], [946]], fluorescently-labeled GIP accumulates after single peripheral administration predominantly in the area postrema (AP) and the median eminence (ME), but not in the BBB shielded regions of the hypothalamus or the hindbrain [580,581]