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Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]

Genetics, diet, exercise, starting weight, metabolic health, and adherence all influence individual outcomes

Risk factors associated with cortical thickness and white matter hyperintensities in dementia free Okinawan elderly

Emerging evidence has suggested that obesogenic diets, including high-fat components, could alter GLP-1 production by affecting the gut microbiota [25,26,27,28,29]

Cleveland Clinic: Massachusetts General Hospital: Preserving Lean Body Mass in Patients Taking GLP-1 for Weight Loss Mayo Clinic: Strength Training: Get Stronger, Leaner, Healthier U.S

[41] In addition, emerging therapeutic targets, such as peroxisome proliferator-activated receptors (PPAR-) agonists, AMPK activators, IRS modulators, and mTOR inhibitors, are currently being explored for their ability to restore metabolic homeostasis and prevent epileptogenic network formation