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Stacking two compounds effectively doubles the receptor stimulation at GLP-1, which means you are operating at a stimulation level that exceeds what any single-agent trial has tested

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Neurodegener Dis Manag 4(1):3140 Talbot K et al (2012) Demonstrated brain insulin resistance in Alzheimers disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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