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Serious risks, such as acute pancreatitis or thyroid C-cell tumors, remain exceptionally rare in human populations, though they warrant careful screening and adherence to contraindications

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doi:10.1006/bbrc.2000.4212 170

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Despite a further increase in mean plasma exposure toward semaglutide steady-state (1.0 mg), the incidence of nausea decreased gradually with each subsequent dose, possibly indicating tolerance development