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Oct 9: In a relatively rare move, the FDA went against the recommendation of one of its advisory committees, rejecting a bid by Alnylam to expand Onpattro (patisiran)s label to cardiomyopathy of transthyretin-mediated amyloidosis

Challenges such as solubility limitations and non-specific binding must be carefully managed

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Even short 1020 min sessions have significant metabolic benefits: Increases post-exercise fat burn (EPOC) Improves insulin sensitivity Mobilises abdominal fat Enhances mitochondrial function in muscle How to Get Started With HIIT Beginner options: 30 sec fast walk / 60 sec normal pace 6 rounds Stationary bike: 15 sec sprint / 45 sec easy 8 rounds Circuit: squats, climbers, jumping jacks, lunges (30 sec on / 30 sec rest) Aim for 24 sessions per week
