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If constipation is particularly troublesome, discuss with your prescriber whether adjusting your GLP-1 medication dose or slowing the titration schedule might help manage symptoms while maintaining therapeutic benefits

Obesity significantly increases loading forces on the knees, hips, ankles, and spine, accelerating cartilage degradation and contributing to osteoarthritis development and progression

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Metformin reduces the synthesis of pro-inflammatory cytokines in macrophages at a molecular level by blocking the transition from monocytes to macrophages via the AMPK-STAT3 pathway (Vasamsetti et al., 2015)

[DOI] [PubMed] [Google Scholar] 31.Holst J.J., Andersen D.B., Grunddal K.V

If mixing is needed, roll gently