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Whilst all GLP-1RAs use has increased, the largest change was seen in patients using tirzepatide and semaglutide ([figure 1B][1])

(For a detailed history, I recommend Megan Molteni and Elaine Chens piece for STAT.) The benefits of these drugs are undeniable, but when it comes to evaluating their risks, we run into challenges that researchers are familiar with but that the public at large may not be aware of

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