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Footnotes: 1: Dan Witters, Mary Page James, Obesity Rate Declining in U.S., Gallup, October 2025 2: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using Google Trends, Reuters, Business Insider, CNBC, ro, Weightwatchers, hims&hers, 23andMe, Noom, Digiday, Edo, Fierce Healthcare, Morgan Stanley, KFF, NIH, ICER 3: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using Circana and Earnest Analytics 4: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using Circana Complete Consumer Total US, June 2022-June 2024 5: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using Circana, Euromonitor, Morgan Stanley Research 6: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using Morgan Stantely 7: Supra n.4 8: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using Stephens, Circana, Morgan Stanley Research 9: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using AlphaWise, Census Bureau, Carbon Arc Medical & Pharmacy Open Claims, Morgan Stanley Research 10: FTI Consulting analysis of publicly-available and licensed subscription data (2026) using GlobalData, Numerator Data, Company Reports, Piper Sandler & Co Published July 02, 2026 Key Contacts Managing Director

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.John G.K., Wang L., Nanavati J., Twose C., Singh R., Mullin G

Conclusions The effect of GIP on systemic metabolic regulation, especially fat accumulation, body weight and appetite, may differ between physiological and pharmacological concentrations in the bloodstream (Graphical Abstract)