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What does evidence say about GLP-1 agonists and suicidal ideation

Anyone considering using or just starting a GLP-1 medication

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In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year

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GLP-1 medications often reduce your appetite, making it difficult to meet your daily nutrient requirements